OMEPRAZOLE

Indications & Dose:

• BY MOUTH

Adult

Benign gastric and duodenal ulcers: 

(including those complicating NSAID therapy), 20mg daily for 4 weeks in duodenal ulceration or 8 weeks in gastric ulceration; in severe or  recurrent cases increase to 40mg daily; maintainance for recurrent duodenal ulcer, 20mg daily.

Duodenal ulcer associated with H. pylori: 

40mg daily with amoxycillin 750mg twice daily for 2 weeks.

Zollinger-Ellison syndrome: 

initially 60mg once daily, usual range 20-120mg daily  (above 80mg in 2 divided doses).

Reflux oesophagitis:  

20mg daily for 4 weeks, followed by a further 4-8 weeks if not fully healed; 40mg daily has been given for 8 weeks in reflux oesophagitis refractory to other treatment; may be continued at 20mg daily.

Acid related dyspepsia:

10-20mg daily for 2-4 weeks,according to response.

BY INJECTABLE

By intravenous injection: 

over 5 minutes or by intravenous infusion: 40mg completely 1 hour before surgery. I|n other disease 40 mg once daily untill oral administration possible.

Children 

Severe ulcerating reflex oesophagitis:

Children 10-20kg; 10mg once daily, increased if necessary to 20mg once daily for 4-12 weekes 

Children over 20kg,; 20mg once daily, increased if necessary to 20mg once daily, increased if necessary to 40mg once daily for 4012 weekes, to be initiated by hospital paediatricians.

Note: Pediatric oral suspention not available

Contraindications:

In pregnancy and lactation.

Side Effects:

CNS: Asthenia, dizziness, headache GI: Abdominal pain, constipation, diarrhea, flatulence, nausea

MS: Back pain

RESP: Cough

SKIN: Rash

Cautions:

Precautions:

Not for maintenance therapy of duodenal ulcer or GERD; elderly; children; symptomatic response does not preclude gastric malignancy.

Old age: May be used.

Interaction:

Drugs

Carbamazepine, diazepam, digoxin, glipizide, glyhuride, nifedipine, nimadipine, nisoldipine, nitrendipine: Increased concentrations of these drugs

Cefpadaxime, cefuraxime, enaracin, ketoconazole: Decreased concentrations of these drugs

Glipizide, glyhrrnide, tolbutamide: Increased absorption of these drugs, potential of hypoglycemia

Methotrexate: Case report of elevated rnethotrexate concentration

Phenytoin: Increased phenytoin concentration

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: