Clinical Pharmacology Details


BISMUTH SUBSALICYLATE


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Indications & Dose:

Adult


BY MOUTH


Diarrhea: PO 30 ml or 2 tabs q30 60 min; not to exceed 8 doses for >2 days


Prevention of travelers’ diarrhea:


PO 30 ml or 2 tabs qid


Helicobacter pylori: PO 2 tabs qid (in combination with other agents) 


Child


Diarrhea: Age 9 12 yr PO 15 mlor 1 tab q30 60 min, not to exceed 8 doses for >2 days; Age 6 9 yr PO 10 ml or 2/3 tab q30 60 min, not to exceed 8 doses for >2 days; Age 3 6 yr PO 5 ml or 1/3 tab q30 60 min, not to exceed 8 doses for >2 days


 

Contraindications:

Child <3 yr

Side Effects:

Cautions:

Precautions:

Anticoagulant therapy; stop use if symptoms do not improve within 2 days or become worse, or if diarrhea is accompanied by high fever or severe abdominal pain


Pregnancy ; salicylate excreted in breast mills


 

Interaction:

Drugs


Tetracyclines: Decreased absorption of tetracyclines


Labs


•Color: Blackens or discolors stool


• Glucose (urine): Interferes with Benedict’s reaction


 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Confusion, twitching


EENT: Blue gums, hearing loss, metallic taste, tinnitus


GI: Black tongue, dark stools, fecal impaction (high doses)


HEME: Increased bleeding time

Patient And Carer Advice: