DIPHENOXYLATE + ATROPINE

Indications & Dose:

Diarrhea, reduction of ileostomy discharge

BY MOUTH

Adults: 4 tablet  initially then 2 tablet 4 hourly until under control.

4-8 years 1 tab three times daily, 9-12 years 1 tab 4 times daily, 13-16 years 2 tab three times daily.

Child:Under 4 year not recommended.

Contraindications:

Obstructive, jaundice, diarrhea associated with pseudomembranous enterocolitis or enterotoxin¬producing bacteria

Side Effects:

Cautions:

Precautions:

Age <2 yr, acute ulcerative colitis (may induce toxic megacolon), severe hepatorenal disease

Pregnancy & breast-feeding: excreted in breast milk use with caution.

Old age: May be given in reduced dose.

Interaction:

Drugs

MAOIs: Possible hypertensive crisis

Barbiturates, tranquilizers, narcotics, alcohol:

Potentiation of effects

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Fatigue, dizziness, drowsiness 

EENT: Dry mouth

GI: Abdominal pain or distention, constipation, ileus, nausea, vomiting

SKIN: Rash (hypersensitivity)

Acts as an antidiarrheal drug whereas Atropine is added to prevent abuse.

Patient And Carer Advice: