Dried prothrombin complex (Human prothrombin complex)

Indications & Dose:

Treatment and peri-operative prophylaxis of haemorrhage in patients with congenital deficiency of factors II, VII, IX, or X if purified specific coagulation factors not available | Treatment and peri-operative prophylaxis of haemorrhage in patients with acquired deficiency of factors II, VII, IX, or X (e.g. during warfarin treatment)

% BY INTRAVENOUS INFUSION

% Adult: (consult haematologist)

Major bleeding in patients on warfarin following phytomenadione (initiated under specialist supervision)

% BY INTRAVENOUS INFUSION

% Adult: 25–50 units/kg

Contraindications:

Angina . history of heparin induced thrombocytopenia . recent myocardial infarction (except in life-threatening haemorrhage following overdosage of oral anticoagulants, and before induction of fibrinolytic therapy)

Side Effects:

% Rare Headache . antibody formation .

% Very rare Anaphylaxishypersensitivity reactions . pyrexia

%  Frequency  not  known  Disseminatedintravascular coagulation . nephrotic syndrome . thrombotic events

HEPATIC IMPAIRMENT Monitor closely in hepatic impairment (risk of thromboembolic complications).

Cautions:

Disseminated coagulation history of myocardial infarction or coronary heart disease . postoperative use . riskof thrombosis

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: