AMLODIPINE

Indications & Dose:

Prophylaxis of angina

•  By MOUTH

Adult: Initially 5 mg once daily; maximum 10 mg per day

Hypertension

• BY MOUTH

Adult: Initially 5 mg once daily; maximum 10 mg per day

DOSE EQUIVALENCE AND CONVERSION

• Tablets from various suppliers may contain different salts (e.g. amlodipine besilate, amlodipine maleate, and amlodipine mesilate) but the strength is expressed in terms of amlodipine (base); tablets containing different salts are considered interchangeable.

Contraindications:

Hypersensitivity

Side Effects:

CNS: Anxiety, asthenia, depression, dizziness, light-headedness, fatigue, headache (7.5%), insomnia, malaise, nervousness, paresthesia, somnolence, tremor

CV: Bradycardia, dysrhythmia, hypotension, palpitations, peripheral edema, syncope, tachycardia

GI: Abdominal cramps, constipation, diarrhea, dry mouth, flatulence, gastric upset, nausea (3%), vomiting

GU: Nocturia, polyuria

SKIN: Hair loss, pruritus, rash, urticaria

MISC: Cough, epistaxis, flushing, muscle cramps, nasal congestion, sexual dysfunction, shortness of breath, sweating, tinnitus, weight gain

Cautions:

Precautions:

CHF, hypotension, hepatic insufficiency, aortic stenosis, elderly 

Interaction:

Drugs

Barbiturates: Reduced plasma concentrations of amlodipine

Diltiazem: Reduced clearance of amlodipine

Erythromycin: Reduced clearance of amlodipine

Fentanyl: Severe hypotension or increased fluid volume requirements

Grapefruit juice: Reduced clearance of amlodipine

H2 blockers: Increased plasma concentration of amlodipine possible

Proton  pump  inhibitors:  Increased  plasma concentration of amlodipine possible

Quinidine: Increased plasma concentration of amlodipine; reduced plasma quinidine level

Rifampin: Reduced plasma concentration of amlodipine

Vincristine: Reduced vincristine, clearance.

Warnings:

Adverse Effects:

Lactations:

Unknown if excreted into milk; use caution in nursing mothers

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: