MANNITOL20%

Indications & Dose:

Cerebral oedema BY INTRAVENOUS INFUSION Adult: 0.25–2 g/kg, repeated if necessary, to be administered over 30-60 minutes, dose may be repeated 1–2 times after 4–8 hour BY INTRAVENOUS INFUSION Adult: 0.25–2 g/kg, repeated if necessary, to be administered over 30–60 minutes, dose may be repeated 1–2 times after 4–8 hours 

Contraindications:

Anuria . intracranial bleeding (except during craniotomy) . severe cardiac failure severe dehydration . severe pulmonary oedema 

Side Effects:

Uncommon  Electrolyte  imbalance  .fluid imbalance . hypotension . thrombophlebitis Rare Anaphylaxis . arrhythmia . blurred vision .chest pain . chills . convulsions . cramp .dehydration . dizziness . dry mouth . fever . focalosmotic nephrosis . headache .hypersensitivity reactions . hypertension . nauseaoedema . pulmonary oedema . raised intracranial pressure . rhinitis . skin necrosis . thirst . urinary retention . urticaria . vomitingVery rare Acute renal failure . congestive heart failurePREGNANCY Manufacturer advises avoid unless essential—no information available.BREAST FEEDING Manufacturer advises avoid unless essential—no information available. RENAL IMPAIRMENT Use with caution in severe impairment.PRE-TREATMENT SCREENING Assess cardiac function before treatment.MONITORING REQUIREMENTS Monitor fluid and electrolyte balance, serum osmolality, and cardiac, pulmonary and renal function.DIRECTIONS FOR ADMINISTRATION For mannitol 20%, an in-line filter is recommended (15-micron filters have been used

Cautions:

Extravasation causes inflammation and thrombophlebitis

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