LISINOPRIL+ HYDROCHLOROTHIAZIDE

Indications & Dose:

Essential hypertension

• BY MOUTH

Adult: Initially 5 mg daily, increased if necessary to 10 mg daily, dose to be taken before food, doses to be increased at intervals of at least 3 weeks; maximum 20 mg per day

Elderly: Initially 2.5 mg daily, increased if necessary to 10 mg daily, dose to be taken before food, doses to be increased at intervals of at least 3 weeks

Essential hypertension in patients with heart failure, angina or cerebrovascular disease, or in renal or hepatic impairment

• BY MOUTH

Adult: Initially 2.5 mg daily, increased if necessary to 10 mg daily, dose to be taken before food, dose to be increased at intervals of at least 3 weeks; maximum 20 mg per day 

Contraindications:

Ischaemic heart orcerebrovascular disease, aortic stenosis, hypertrophic cardiomyopathy, those at risk of symptomatic hypotension and patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney. History of angioedema and black hypertensive patients, may be at increased risk of angioedema with an ACE inhibitor. Use in

pregnancy not recommended.

Side Effects:

Blurred vision . bronchitis .confusion .depression . dry mouth . dyspnoea . glossitis .ileus . impotence . sleep disturbances . tinnitus l

BREAST FEEDING Not recommended; alternative treatment options, with better established safety information during breast-feeding, are available. 

HEPATIC IMPAIRMENT Imidapril is a prodrug and requires close monitoring in patients with hepatic impairment.

RENAL IMPAIRMENT Initial dose 2.5mg daily if eGFR 30–80 mL/minute/1.73m2. Avoid if eGFR less than 30 mL/minute/1.73m2.

Cautions:

Hepatic disease and diabetes. During breast feeding take account of the potential for serious reactions. Use of other antihypertensives, potassium sparing diuretics, potassium supplements, potassium containing salt substitutes, tubocurarine, indomethacin (and other NSAID’s in patients with compromised renal function) and lithium.

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