ALISKIREN

Indications & Dose:

Essential hypertension either alone or in com-bination with other antihypertensives

• BY MOUTH

Adult: 150 mg once daily, increased if necessary to300 mg once daily

Children Not recommended.

Contraindications:

Concomitant treatment with an ACE inhibitor or an angiotensin-II receptor antagonist in patients with an eGFR less than 60mL/minute/1.73m2 . concomitant treatment with an ACE inhibitor or an angiotensin-II receptor antagonist in patients with diabetes mellitus .hereditary angioedema . idiopathic angioedema

Side Effects:

Cautions:

Combination treatment with an ACE inhibitor  . combination  treatment  with  an angiotensin-II receptor antagonist . concomitant use of diuretics(first doses may cause hypotension—initiate with care) . history of angioedema . moderate to severe congestive heart failure . patients at risk of renal impairment . salt depletion (first doses may cause hypotension—initiate with care) . volume depletion (first doses may cause hypotension—initiate with care)

Precautions:

patients taking concomitent diuretic, on a low sodium diet or who are dehydrated ( 1st dose may cause hypotension, use with caution in Renal and Hepatic impairment

PREGNANCY Manufacturer advises avoid—no information available; other drugs acting on the renin-angiotensin ystem have been associated with fetal malformations and neonatal death.

BREAST FEEDING Present in milk in animal studies—manufacturer advises avoid.

RENAL IMPAIRMENT Avoid if eGFR is less than 30 mL/minute/1.73m2—no information available. Use with caution in renal artery stenosis—no information available. Monitor plasma-potassium concentration in renal impairment.

Interaction:

Warnings:

Adverse Effects:

diarrhoea, ,less commonly rash, rarely angioedema, anemia, hyperkalemia

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: