HYDROCHLORIDE

Indications & Dose:

Acute hypotension BY SUBCUTANEOUS INJECTION, OR BY INTRAMUSCULAR INJECTION Adult: Initially 2–5 mg, followed by 1–10 mg, after at least 15 minutes if required BY SLOW INTRAVENOUS INJECTION Adult: 100–500 micrograms, repeated as necessary after at least 15 minutes BY INTRAVENOUS INFUSION Adult: Initially up to 180 micrograms/minute,reduced to 30–60 micrograms/minute, adjusted according to response

Contraindications:

Hypertension severe hyperthyroidism

Side Effects:

hypertension, headache, bradycardia, arrhythmia, peripheral ischaemia, anorexia, nausea, vomiting, hypoxia, dysnea, insomnia, confusion, anxiety, tremor, urinary retention.

Cautions:

coronary, mesenteric, or peripheral vascular thrombosis; following myocardial infarction, Prinz metal’s variant angina, hyperthyroidism, diabetes mellitus; hypoxia or hypercapnia; uncorrected hypovolaemia; elderly; extravasation at injection site may cause necrosis; interactions PREGNANCY Avoid if possible; malformations reported following use in first trimester; fetal hypoxia and bradycardia reported in late pregnancy and labour

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