PRASUGREL

Indications & Dose:

In combination with aspirin for the prevention of atherothrombotic events in patients with acute coronary syndrome undergoing percutaneous coronary intervention

• BY MOUTH

Adult 18–74 years (body -weight up to 60 kg): Initially 60 mg for 1 dose, then 5 mg once daily usually for up to 12 months

Adult 18–74 years (body-weight 60 kg and above): Initially 60 mg for 1 dose, then 10 mg once daily usually for up to 12 months

Adult 75 years and over: Initially 60 mg for 1 dose, then 5 mg once daily usually for up to 12 months

Patients undergoing coronary angiography within 48 hours of admission for unstable angina or NSTEMI

• BY MOUTH

Adult: Loading dose 60 mg, not to be administered until the time of percutaneous coronary intervention in order to minimise the risk of bleeding, maintenance dose of 10 mg or 5mg daily should then be selected as appropriate based on age and weight

Alternative to clopidogrel in certain patients undergoing percutaneous coronary intervention l

• BY MOUTH

Adult: 60 mg, as a single dose

Contraindications:

Active bleeding, history of transient isch-emic attack or stroke, hypersensitivity to prasugrel or its components PREGNANCY: C (Risk cannot be ruled out).Lactation: > (Caution advised or effect undetermined).

Side Effects:

Cautions:

Precautions:

Patients at increased risk of bleeding (e.g. from recent trauma, surgery, gastrointestinal bleeding or active peptic ulcer disease); concomitant use of drugs that increase risk of bleeding; discontinue at least 7 days before elective surgery if antiplatelet effect not desirable; elderly; body-weight less than 60 kg.

Interaction:

NSAIDs, coumarins, phenindione, clopidogrel.

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS:  Dizziness,  fatigue,  fever,  headache,intracranial hemorrhage

CV: Atrial fibrillation, bradycardia, hyper-cholesterolemia, hyperlipidemia, hypertension, hypotension, peripheral edema

EENT: Epistaxis, retinal hemorrhage

GI: Diarrhea, GI or retroperitoneal hemorrhage,hepatic dysfunction, nausea

HEME: Anemia, leukopenia, mild to life-threatening bleeding, severe thrombocyto-penia, thrombotic thrombocytopenic purpura

MS: Back or limb pain

RESP: Cough, dyspnea,hemoptysis

SKIN: Subcutaneous hematoma, rash

Other: Allergic reaction, anaphylaxis, angioedema, malignancies, noncardiac chest pain

Patient And Carer Advice: