COLFOSCERIL PALMITATE

Indications & Dose:

Neonatal respiratory distress syndrome (RDS): Prophylactic Therapy: Infants at risk for developing RDS with body weight <1350 gm; infants with evidence of pulmonary immaturity with body weight > 1350 gm. Rescue Therapy: Treatment of infants with RDS based on respiratory distress not attributed to any other causes and chest radiographic findings consistent with RDS.

Dosage: Intratracheal: Prophylactic treatment: Give 5 mL/ kg as soon as possible; the sec and third dose should be administered at 12 and 24 hr later to those infants remaining on ventilators.

Rescue treatment: Give 5 mL/kg as soon as the diagnosis of RDS is made, The sec 5 mg/kg dose should be administered 12 hr later.

ADMINISTRATION: Intratracheal: For intratracheal administration only. Suction infant prior to administration, inspect solution to verify complete mixing of the suspension. Administer via side port on the special ETT adapter without interrupting mechanical ventilation. Administer the dose in two 2.5 ml/ kg aliquots. Each half-dose is instilled slowly over 1 -2 min in small bursts with each inspiration. After the first 2.5 mL/kg dose turn the infants head and torso 45 degree right for 30 seconds, then return to the midline position and administer the second dose as above. Following the second dose, turn the infant's head and torso 45 degree to the left for 30 seconds and return the infant to the midline position. 

Contraindications:

Side Effects:

Cautions:

Precautions:

: Preterm birth. Also see literature

Interaction:

Warnings:

Adverse Effects:

Rarely, pulmonary haemorrhage

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: