DOXOFYLLINE

Indications & Dose:

   Treatment of bronchial asthma and pulmonary disease with spastic bronchial comp

• BY MOUTH

Tablets:

Elderly Patients: 1/2 tablet two or three times daily.

Adults: 1 tablet two or three times daily

Syrup:

Elderly Patients: 10ml (2 teaspoonful), two or three times daily.

Children greater than 12 years old: 10ml (2 teaspoonful), two or three times daily.

Children less than 12 years old: 6 — 9 mg/kg twice daily 

Contraindications:

Known hypersensitivity to its components. Acute myocardial infarction, hypotension and in lactating women. 

Side Effects:

After xanthine administration, nausea, vomiting, epigastric pain, cephalagia, irritability, insomnia, tachycardia, extrasystole, tachypnea, and occasionally hyperglycemia and albuminuria, may occur, if a potential oral oversdose is established, the patient may present with severe arrhythmias and seizure; these symptoms could be the first sign of an intoxication. Adverse reactions may cause the withdrawal from treatment; a lower dose rechallenge may start only after the advice of physician. 

Cautions:

Precautions:

Interaction:

Doxofylline should not be administered together with other xanthine derivatives, including beverages and foods containing caffeine. Toxic synergism with ephedrine has been documented for xanthines. Concomitant therapy with erythromycin, troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, propranolol and anti-flu vaccine may decrease the hepatic clearance of xanthines causing an increase in blood levels.

Warnings:

Adverse Effects:

Lactations:

 Should be given to a pregnant woman only if clearly needed. Doxofylline is contraindicated in nursing mothers

Special Precautions:

The half-life of xanthine derivatives is influenced by a number of known variables. It may be prolonged in patients with liver disease. In patients with congestive heart failure, in those affected with chronic obstructive lung disease or concomitant infection, and in those patients taking certain other drugs (erythromycin, troleandomycin, lincomycin, and other antibiotics of the same group, allopurinol, cimetidine, propranolol, and anti-flu vaccine). In these cases, a lower dose of Ooxofylline may be needed. Phenytoin, other anti-convulsants and smoking may cause an increase in clearance with a shorter mean half-life: in these cases higher doses of Doxofylline may be needed. Use with cautions in patients with hypoxemia, hyperthyroidism, liver disease, renal disease, in those with history of peptic ulcer and in elderly. Frequently, patients with congestive heart failure have markedly prolonged drug serum levels following discontinuation of the drug. 

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: