MEMANTINE HYDROCHLORIDE

Indications & Dose:

Moderate to severe dementia in Alzheimer’s disease

• BY MOUTH

Adult: Initially 5 mg once daily, then increased in steps of 5 mg every week; usual maintenance 20 mg daily; maximum 20 mg per day.

Children Not recommended. 

Contraindications:

Severe renal impairment, lactation. 

Side Effects:

Common or very common Balance disorders . constipation . dizziness . drowsiness . dyspnoea . headache . hypertension

Uncommon Abnormal gait . confusion . fatigue . hallucinations . heart failure . thrombosis . vomiting

Very rare Seizures

Frequency not known Depression . hepatitis . pancreatitis . psychosis . suicidal ideation

Cautions:

Precautions:

Moderate renal impairment, epilepsy or predisposition to epilepsy, history of convulsions, recent MI, uncompensated heart failure, uncontrolled hypertension. Pregnancy

Interaction:

Drug

Amantadine, ketamine, dextromethorphan, levodopa, dopaminergic agonist, anticholenergics, barbiturates, neuroleptics, baclofen, dantrolene, cimetidine, ranitidine, procainamide, quinidine, quinine, nicotine, hyperchlorothiazide

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: