CHLORDIAZEPOXIDE

Indications & Dose:

• BY MOUTH

• Mild anxiety:

5-10 mg tid-qid 

• Severe anxiety:

20-25 mg tid qid; IMAV 50-100 mg initially, then 25-50 mg tid-qid prn

• Preoperative apprehension and anxiety:

5-10 mg tid-qid on days before surgery; IM 50-100 mg 1 hr before surgery

• Acute alcohol withdrawal:

50-100 mg initially; repeat in 2-4 hr prn; not to exceed 300 mg/day

• Geriatric or debilitated patients 

5 mg bid-qid

Child >6 yr: 5 mg bid-qid, not to exceed 10 mg bid-tid 

Contraindications:

 Narrow angle glaucoma, psychosis 

Side Effects:

Cautions:

Precautions:

 Elderly, debilitated, hepatic disease, renal disease, long-term use, history of drug abuse

Interaction:

Drugs

Cimetidine: Increased plasma levels of chlordiazepoxide and/or active metabolites

Disulfiram: Increased serum chlordiazepoxide concentrations

Ethanol: Enhanced adverse psychomotor side effects of benzodiazepines

Fluconazole, itraconazole, ketoconazole: Increased chlordiazepoxide concentrations

Levodopa: Potential for exacerbation of Parkinsonism in patients taking levodopa

Warnings:

Adverse Effects:

Lactations:

Excreted into breast milk; drug and metabolites may accumulate to toxic levels in nursing infant 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Anterograde amnesia, anxiety, ataxia, confusion, depression, dizziness, drowsiness, fatigue, hallucinations, headache, hysteria, insomnia, Asychosis, slurred speech, stimulation, tremor

CV: Bradycardia, hypertension, hypotension, orthostatic hypotension, shock, tachycardia

EENT: Auditory disturbances, blurred vision, mydriasis, nystagmus

GI: Anorexia, constipation, diarrhea, dry mouth, nausea, vomiting

GU: Changes in libido, incontinence, menstrual irregularities, urinary retention

SKIN: Dermatitis, hair loss, hirsutism, itching. rash, urticaria 

Patient And Carer Advice: