HALOPERIDOL

Indications & Dose:

Note: 2 mg equivalent to chlorpromazine 100 mg

Adult and Child >16 yr

• Psychosis/Touretteís syndrome:

PO 0.5-1.5 mg bid or tid initially depending on severity of conditions, dose is increased to desired dose, max 100mg/day; IM 2-5 mg q1-8h

• Chronic schizophrenia:

IM 10-15 times the individual patients stabilized PO dose q4 wk (decanoate)

Child 3-12 hr

• Psychosis:

PO/IM 0.05-0.15 mg/kg/day in 2-3 divided doses

• Hyperactivity: PO 0.05-0.075 mg/kg/day in 2-3 divided doses

Children

Tourette’s syndrome:

up to 10mg daily doses

Contraindications:

Side Effects:

Cautions:

Precautions:

Interaction:

Drugs :

Anticholinergics: Inhibition of therapeutic effect of neuroleptics

Barbiturates: Potential reduction of serum neuroleptic concentrations

Bromocriptine: Inhibition of bromocriptineís ability to lower serum prolactin concentrations in patients with pituitary adenoma; theoretical inhibition of antipsychotic effects of neuroleptics

Carbamazepine: Decreased serum haloperidol concentrations

Guanethidine: Inhibition of antihypertensive effect of guanethidine

Levodopa: Inhibition of antiparkinsonian effects of levodopa

Lithium: Rare reports of severe neurotoxicity in patients receiving lithium and neuroleptics

Quinidine: Increases haldol concentrations; increased risk of toxicity.

Warnings:

Adverse Effects:

Lactations:

Has been used for hyperemesis gravidarum, chorea gravidarum, and manic-depressive illness during pregnancy; excreted into breast milk; effect on nursing infant unknown, but may be of concern

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Agitation, anxiety, catatonic-like behavioral states, confusion, depression, drowsiness, EPS (pseudoparkinsonism, akathisia, dystonia, tardive dyskinesia), euphoria, exacerbation of psychotic symptoms including hallucinations, headache, insomnia, lethargy, neuroleptic malignant syndrome, restlessness, seizures, vertigo

CV: ECG changes, hypertension, hypotension, tachycardia

EENT: Blurred vision, cataracts, dry eyes, glaucoma, retinopathy

GI: Anorexia, constipation, diarrhea, dry mouth, dyspepsia, hypersalivation, nausea, vomiting

GU: Priapism, urinary retention

HEME: Arganulocytosis, anemia, leukocytosis, minimal decreases in red blood cell counts, transient leukopenia.

METAB: Breast engorgement, gynecomastia, hyperglycemia, hyperprolactinemia, hypoglycemia, hyponatremia, impotence, increased libido, lactation, mastalgia, menstrual irregularities

RESP: Bronchospasm, increased depth of respiration, laryngospasm

SKIN: Diaphoresis, isolated cases of photosensitivity, loss of hair, maculopapular and acneiform skin reactions.

Patient And Carer Advice: