LOPERIDONE

Indications & Dose:

Atypical antipsychotic agent indicated for the acute treatment of schizophrenia in adults.

BY MOUTH

Adult:  Initial 1mg two times daily.Titrates 2mg 2 times daily, on day 2 4mg 2 times daily, on day 3, 6mg daily day 4, 8mg daily, day 5, 10mg daily, day 6, 12mg dailytwo times dailyon day 7 6-12mg two times daily Max: 12mg daily

Children: Not recommended

Contraindications:

Dementia-related psychosis. 

Side Effects:

Cautions:

Precautions:

Elderly patients with dementia related psychosis. Avoid use in combination with other drugs that’s known to prolong Qtc.. Neuroleptic malignant syndrome. Tardive dyskinesia. Use cautiously in patients with a history of seizures, use caution when operating machinery.

Interaction:

DRUGS antibiotics such as fluoroquinolones or macrolides, class IA antiarrhythmics such as procainamide or quinidine, class III antiarrhythmics such as amiodarone or sotalol, other antipsychotic drugs such as chlorprom-iazine or thioridazine, or any other drug that affects the QT interval, such as

metha-done or pentamidine: Possibly prolonged QT interval antihypertensive drugs: Increased antihypertensive effects CYP3A4 inhibitors such as ketoconazole, CYP2D6 inhibitors such asfluoxetine or paroxetine: Increased plasma iloperidone level dextromethorphan: Increased blood dextromethorphan level 

Warnings:

Adverse Effects:

Lactations:

Not recommended 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Aggression, delusion, dizziness, extrapyramidal effects, fatigue, lethargy, seizures, somnolence, suicidal ideation, restlessness, tremor

CV: CHF, dyslipidemia, orthostatic hypotension, palpitations, QT-interval prolongation, tachycardia

EENT: Blurred vision, conjunctivitis, dry mouth, nasal congestion, nasopharyngitis, upper respiratory tract infection

ENDO: Diabetic ketoacidosis, elevated prolactin levels, hyperglycemia, hyperosmo-lar coma

GI: Abdominal discomfort, diarrhea, nausea

GU: Ejaculation failure, erectile dysfunction, priapism, urinary incontinence

HEME: Leukopenia

MS: Arthralgia, musculoskeletal stiffness, spasms, myalgia

RESP: Dyspnea

SKIN: Rash

Other: Weight gain 

Patient And Carer Advice: