Indications & Dose:
Schizophrenia
Adult: 25 mg twice daily for day 1, then 50 mg twice daily for day 2, then 100 mg twice daily for day 3, then 150 mg twice daily for day 4, then, adjusted according to response, usual dose 300–450 mg daily in 2 divided doses, the rate of dose titration may need to be slower and the daily dose lower in elderly patients; maximum 750 mg per day
¶% Adult: 300 mg once daily for day 1, then 600 mg once daily for day 2, then, adjusted according to response, usual dose 600 mg once daily, maximum dose under specialist supervision; maximum 800 mg per day
Treatment of mania in bipolar disorder
Adult: 50 mg twice daily for day 1, then 100 mg twice daily for day 2, then 150 mg twice daily for day 3, then 200 mg twice daily for day 4, then adjusted in steps of up to 200 mg daily, adjusted according to response, usual dose 400–800 mg daily in 2 divided doses, the rate of dose titration may need to be slower and the daily dose lower in elderly patients; maximum 800 mg per day
Adult: 300 mg once daily for day 1, then 600 mg once daily for day 2, then, adjusted according to response, usual dose 400–800 mg once daily
Elderly: Initially 50 mg once daily, adjusted according to response. adjusted in steps of 50 mg daily continued.
Treatment of depression in bipolar disorder
Adult: 50 mg once daily for day 1, dose to be taken at bedtime, then 100 mg once daily for day 2, then 200 mg once daily for day 3, then 300 mg once daily for day 4, then, adjusted according to response; usual dose 300 mg once daily, the rate of dose titration may need to be slower and the daily dose lower in elderly patients; maximum 600 mg per day
Adult: 50 mg once daily for day 1, dose to be taken at bedtime, then 100 mg once daily for day 2, then 200 mg once daily for day 3, then 300 mg once daily for day 4, then, adjusted according to response; usual dose 300 mg once daily; maximum 600 mg per day
Prevention of mania and depression in bipolar disorder
Adult: Continue at the dose effective for treatment of bipolar disorder and adjust to lowest effective dose; usual dose 300–800 mg daily in 2 divided doses
Adult: Continue at the dose effective for treatment of bipolar disorder and adjust to lowest effective dose; usual dose 300–800 mg once daily
Adjunctive treatment of major depression
Adult: 50 mg once daily for 2 days, dose to be taken at bedtime, then 150 mg once daily for 2 days, then, adjusted according to response, usual dose 150–300 mg once daily
Elderly: Initially 50 mg once daily for 3 days, then increased if necessary to 100 mg once daily for 4 days, then adjusted in steps of 50 mg, adjusted according to response, usual dose 50–300 mg once daily, dose of 300mg should not be reached before day 22 of treatment
Contraindications:
Side Effects:
Cautions:
Precautions:
Renal or hepatic impairment, cardiovascular disease, thyroid disorders, hyperprolactinemia
Interaction:
Warnings:
Adverse Effects:
Lactations:
Pregnancy category not available
Special Precautions:
Counselling:
Side Effects Or Adverse Reactions:
CNS: Agitation, dizziness, dystonia and other extrapyramidal symptoms, headache, hostility, insomnia, somnolence
CV: Increased heart rate, orthostatic hypotension
GI: Abdominal pain, asymptomatic elevations of serum transaminases, constipation, dry mouth, dyspepsia
METAB: Weight gain
Patient And Carer Advice:
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