RASAGILINE

Indications & Dose:

Parkinsonism, use  alone or combination with co-beneldopa or co-careldopa

• BY MOUTH

Adult: Monotherapy 1mg daily,

Adjunctive therapy 0.5mg once daily. Titrate may increase to 1mg once daily. Adjust dose of levodopa with concomitant use.

Children: Not recommended

Contraindications:

Acute MI; angina; cardiac arrhythmias; coronary artery disease; cerebrovascular disease; elective surgery that requires general anesthesia; hypersensitivity to rasagiline or its components; pheochromo-cytoma; moderate to severe hepatic impairment; stroke; use within 14 days of cyclobenzaprine, dextromethorphan, MAO inhibitors, meperidine, mirtazapine, ramadol, methadone, propoxyphene, St. Johns wort, or sympathomimetic amines 

Side Effects:

Cautions:

Precautions:

Risk can not be rule out.

Breast-feeding: Use with caution.

Old age: Use with caution.Mild to moderate hepatic impairment, avoid abrupt withdrawal. 

Interaction:

DRUGS ciprofloxacin and other CYP1A2 inhibitors: Increased rasagiline plasma level dextromethorphan: Increased risk of psychosis or bizarre behavior levodopa, levodopa and carbidopa: Increased risk of dyskinesias MAO inhibitors, sympathomimetics: Increased risk of hypertensive crisis meperidine, methadone, propoxyphene, tramadol: Increased risk of life-threatening adverse reactions characterized by coma, severe hypertension or hypotension, severe respiratory depression, seizures, malignant hyperpyrexia, excitation, and peripheral vascular collapse selective serotonin reuptake inhibitors, tetracyclic antidepressants, tricyclic antidepressants: Increased risk of severe CNS toxicity with hyperpyrexia, behavioral and mental status changes, diaphoresis, muscle rigidity, hypertension, syncope, and possible death

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Abnormal dreams, amnesia, anxiety, asthenia, ataxia, cerebral ischemia, coma, confusion, depression, difficulty thinking, dizziness, dyskinesia, dystonia, fever, hallucinations, headache, malaise, manic depressive reaction, nightmares, paresthesia, seizures, somnolence, stroke, stupor, syncope, vertigo

CV: Angina, bundle branch heart block, chest pain, heart failure, MI, hypertensive crisis, postural hypotension, thrombophlebitis, ventricular tachycardia or fibrillation

EENT: Blurred vision, conjunctivitis, dry mouth, gingivitis, hemorrhage, laryngeal edema, retinal detachment or hemorrhage, rhinitis

GI: Abdominal pain, anorexia, constipation, diarrhea, dyspepsia, dysphagia, epistaxia, gastroenteritis, gastrointestinal hemorrhage, intestinal obstruction or perforation, liver function test abnormalities, nausea, vomiting

GU: Acute renal failure, albuminuria, decreased libido, hematuria, impotence, incontinence, priapism

HEME: Anemia, leukopenia, thrombocytopenia

MS: Arthralgia, arthritis, bone necrosis, bursitis, leg cramps, myasthenia, neck pain or stiffness, tenosynovitis

RESP: Apnea, asthma, cough, dyspnea, pleural effusion, pneumothorax, interstitial pneumonia

SKIN: Alopecia, carcinoma, diaphoresis, ecchymosis, exfoliative dermatitis, pruritus, ulcer, vesiculobullous rash

Other: Angioedema, flu syndrome, hypersensitivity reaction, hypocalcemia, weight loss

Patient And Carer Advice: