Clinical Pharmacology Details


ENFLURANE


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Indications & Dose:

 Induction & maintainance of anaesthesia.


DOSE 


Using a specifically calibrated vaporiser, induction, increased gradually  from 0.4% to max. Of 4.5% in air, oxygen, or nitrous oxide-oxygen, according to response. Maintenance, 0.5-3% in nitrous oxideoxygen


ADVANTAGES: Rapid induction & recovery, little biotransformation and therefore little risk of hepatic dysfunction, muscle relaxation, low incidence of arrythmia


DISADVANTAGES: Relatively high cost, seizure activity on EEG. 

Contraindications:

 Epilepsy & renal disease

Side Effects:

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Precautions:

Interaction:

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Lactations:

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Counselling:

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Patient And Carer Advice: