GLYCOPYRROLATE + NEOSTIGMINE

Indications & Dose:

Reversal of residual non-depolarizing (competitive) neuromuscular block.

Adults and older patients: 1-2ml intravenously over a period of 10-30 seconds (equivalent to neostigmine methylsulphate 2.5mg with glycopyrolate 0.5mg to neostigmine methylsulphate 5mg with glycopyrrolate 1mg). Alternatively 0.02 ml/kg intravenously over a period of 10-30 seconds may be used (equivalent) to neostigmine methylsulphate 50 micrograms/kg with glycopyrrolate 10 micrograms /kg)

Children: 0.02 ml/kg intravenously over a period of 10-30 seconds (equivalent to neostigmine methylsulphate 50 micrograms/kg (0.05 mg/kg) with glycopyrrolate 10 micrograms/kg 10 micrograms/kg (0.01 mg/kg). Alternatively dilute to 10 ml with water for injections BP, or sodium chloride injection BP 0.09% w/v and administer 1ml per 5 kg bodyweight.

These doses may be repeated if adequate reversal of neuromuscular blockade is not achieved total doses in excess of 2ml are not recommended as this dose of neostigmine may produce depolarizing neuromuscular block.

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Storage: Store at room temperature not exceeding 25½C 

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