VECURONIUM BROMIDE

Indications & Dose:

Neuromuscular blockade (intermediate duration) during surgery and intubation

• INITIALLY BY INTRAVENOUS INJECTION

Adult: 80–100 micrograms/kg; (by intravenous injection) maintenance 20–30 micrograms/kg, adjusted according to response, max. 100 micrograms/kg in caesarian section, alternatively (by intravenous infusion) maintenance 0.8–1.4 micrograms/kg/minute, adjusted according to response

DOSES AT EXTREMES OF BODY-WEIGHT

To avoid excessive dosage in obese patients, dose should be calculated on the basis of ideal bodyweight

Contraindications:

 Hypersensitivity. 

Side Effects:

Transient fall in blood pressure, slight increase in heart rate, reduction in  GI motility, rarely bronchospasm and anaphylactoid reaction.

Cautions:

 Reduce dose in renal, hepatic failureimpairment.

Precautions:

 Dose adjustment may be required in infants. Severe obesity. Malignant hyperthermia.

Pregnancy:  Safety not established.

Breast-feeding: Use only if clearly indicated.

Old age: Use with caution.

Interaction:

Drugs

Incompatibility with alkaline solution (barbiturates such as thiopentone sodium).

Inhalational anaesthetics: Halothane, isoflurane may enhance effect.

Antiarrhythmic: Lignocaine, quinidine and verapamil may enhanced effect.

Antibacterials: Aminoglycosides, lincosamide, polymixins and rarely tetracyclines may enhance effect.

Anticholinestrases: Neostigmine may enhance effect.

Antiepileptics: Carbamazepine, and pheny-toin may reduce effect.

Ganglion blockers: May enhance effect.

Xanthines: Aminophylline and theophylline may antagonise the effect.

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: