NALOXONE HCL

Indications & Dose:

Complete or partial reversal of narcotic depression, including respiratory depression; diagnosis of suspected acute opioid overdosage; reversal of alcoholic coma,* refractory shock, * Alzheimer’s type dementia, schizophrenia,* anaphylaxis*

Adult

• Narcotic overdose (known or suspected):

SC/IM/1V 0.4 2 mg initially, repeat at 2 3 min intervals up to 10 mg, if no response after 10 mg reevaluate diagnosis

• Postoperative narcotic depression (partial reversal):

IV 0. I  0.2 mg at 2--3 min intervals to desired level of reversal (adequate ventilation and alertness without significant pain or discomfort); repeat doses may be required within 1 2 hr intervals

Child

• Narcotic overdose (known of suspected):

SC/1M/IV 0.01 mg/kg initially, give subsequent doses of 0.01 mg/kg prn at 2 3 min intervals

• Postoperative narcotic depression (partial reversal):

IV 0.005 0.01 mg q2 3 min to desired degree of reversal

Neonates:

BY SUBCUTANEOUS, INTRAMUSCULAR, OR INTRAVENOUS INJECTION

10micrograms/kg, repeated every 2 to 3 minutes or 200 micrograms  (60 micrograms / kg)  by intramuscular injection as a single dose at birth (onset of action slower)

Contraindications:

Side Effects:

Cautions:

Precautions:

Physical narcotic dependency, pre existing cardiovascular disorders

Interaction:

Warnings:

Adverse Effects:

Lactations:

Excretion into breast milk unknown, use caution in nursing mothers 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Seizures, tremulousness

CV: Hypertension, hypotension, tachycardia, ventricular dysrhythmia

GI: Nausea, vomiting

RESP: Pulmonary edema

SKIN: Sweating

MISC: Reversal of analgesia

Patient And Carer Advice: