Pentazocine

Indications & Dose:

Moderate to severe pain. kg body weight

DOSE

Adult

• PO 25- 100mg three to four hourly after meals

• Inj 30-60mg i.m, sc, iv three to four hourly after meals

Children

• Under 1 year not recommended, 1-2 year max; single dose 1mg/kg body weight i.m or sc or 0.5mg/

INDICATIONS AND DOSE:

Moderate to severe pain.

Adult

BY MOUTH

Pentazocine hydrochloride 50mg every 3-4 hours preferable after food (range 25-100mg).

Child 12 years 25mg by intramuscular, or intravenous injection, moderate pain, pentazocine 30mg, severe pain 45-60mg  every 3-4 hours when necessary

Child Over 1 year,

• BY INTRAMUSCULAR INJECTION,

Up to 1 mg/kg, by intravenous injection up to 500 micrograms/kg. By  rectum in suppositories, pentazocine 50mg  up to 4 times daily. Child Under 1 year not recommended. 

Contraindications:

Hypersensitivity to pentazocine or its components 

Side Effects:

Cautions:

Precautions:

Head injury, increased intracranial pressure, acute abdominal conditions, elderly, severe impairment of hepatic or renal function, hypothyroidism, Addison’s disease, prostatic hypertrophy, urethral stricture, history of drug abuse, impaired respiration, bronchial asthma, cyanosis, obstructive respiratory conditions, acute MI (see Special Considerations), chronic opiate use (may precipitate withdrawal symptoms), children 

Interaction:

Drugs

Aspirin: Increased risk of papillary necrosis

Barbiturates: Additive CNS depression

Phenothiazines: Additive CNS depression

Warnings:

Adverse Effects:

Lactations:

 Use during labor may produce neonatal respiratory depression 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Agitation, dependency, dizziness, drowsiness, euphoria, lethargy, restlessness, sedation

CV: Circulatory depression, increased blood pressure, shock, tachycardia

EENT: Blurred vision, diplopia, miosis, nystagmus

GI: Anorexia, constipation, nausea, vomiting

GU: Urinary retention

HEME: Eosinophilia, granulocytopenia, leukopenia

RESP: Respiratory depression, respiratory paralysis

SKIN: Flushing, rash, urticaria 

Patient And Carer Advice: