ERTAPENEM

Indications & Dose:

Abdominal infections Acute gynaecological infections Community-acquired pneumonia

• BY INTRAVENOUS INFUSION

Adult: 1 g once daily

Diabetic foot infections of the skin and soft-tissue

•  BY INTRAVENOUS INFUSION 

Adult: 1 g once daily

Surgical prophylaxis, colorectal surgery

• BY INTRAVENOUS INFUSION 

Adult: 1 g for 1 dose, dose to be completed within 1 hour before surgery 

Contraindications:

Hypersensitivity to amide anesthetics (for IM administration, given with lidocaine), anaphylaxis to 13-lactams 

Side Effects:

Common or very common Diarrhoea . headache . injectionsite reactions . nausea . pruritus . raised platelet count . rash (also reported with eosinophilia and systemic symptoms) . vomiting % Uncommon Abdominal pain . anorexia . antibioticassociated colitis . asthenia . bradycardia . chest pain . confusion . constipation . dizziness . dry mouth . dyspepsia . dyspnoea . hypotension . melaena . oedema . petechiae . pharyngeal discomfort . raised glucose . seizures . sleep disturbances . taste disturbances Rare Agitation . anxiety . arrhythmia . blood disorders . cholecystitis . cough . depression . dysphagia . electrolyte disturbances . haemorrhage . hypoglycaemia . increase in blood pressure . jaundice . liver disorder . muscle cramp . nasal congestion . neutropenia . pelvic peritonitis . renal impairment . scleral disorder . syncope . thrombocytopenia . tremor . wheezing

Frequency not known Dyskinesia . hallucinations

ALLERGY  Use with caution in patients with sensitivity to betalactam antibacterials.

 PREGNANCY Manufacturer advises avoid unless potential benefit outweighs risk.

 BREAST FEEDING Present in milk— manufacturer advises avoid.

 RENAL IMPAIRMENT Risk of seizures; max. 500mg daily if eGFR less than 30 mL/minute/ 1.73m2. 

Cautions:

Precautions:

CNS disorders including meningitis (increased seizure risk), renal impairment (increased seizure and hematologic risks), hypersensitivity to 13-lactams (penicillin, cephalosporins) 

Interaction:

Drugs 

Probenecid: Increased ertapenem half-life 

Warnings:

Adverse Effects:

Lactations:

Pregnancy category B; excreted into breast milk, bottle feeding recommended during and for 5 days after therapy

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: