IMIPENEM/IMIPEMIDE

Indications & Dose:

Serious infections of the lower respiratory tract, urinary tract, skin; intra-abdominal infections, gynecologic infections, septicemia, endocarditis Antibacterial spectrum usually includes

DOSE

Adult

• BY DEEP INTRAMUSCULAR injection, mild to moderate infections, 500-750 mg every 12 hours, Gonococcal urethritis or cervicitits, 500 mg as a single dose.


• BY INTRAVENOUS INFUSION, 1-2g daily in 3- 4 divided doses; less sensitive organisms, up to 50 mg/kg daily (to max. 4 g daily)

Children

3 months and older, 60 mg/kg (up to max. of 2 g) daily in 4 divided doses.

Surgical prophylaxis by intravenous infusion,

1 g at induction of anaesthesia repeated after 3 hours, supplemented in high risk (e.g. colorectal) surgery by doses of 500 mg 8 and 16 hours after induction.

NOTE: Children not recommended by i.m route

Contraindications:

IM: hypersensitivity to local anesthetics of the amide type (contains lidocaine)

Side Effects:

CNS: Dizziness, fever, myoclonus, seizures, somnolence, weakness

CV: Hypotension, palpitations

GI: Diarrhea, glossitis, hepatitis, nausea, pseudomembranous colitis, vomiting

GU: Proteinuria, increased BUN/creatinine

HEME: Eosinophilia, neutropenia

RESP: Chest discomfort, dyspnea, hyperventilation

SKIN: Erythema at inj site, pain at inj site, phlebitis, pruritus, rash, urticaria 

Cautions:

Precautions:

 Elderly, hypersensitivity to penicillins, seizure disorders, renal disease, children < 12 yr 

Interaction:

Drugs Cyclosporine, tacrolimus: Risk of CNS toxicity

Theophylline: Increased seizure risk without elevated theophylline levels

Warnings:

Adverse Effects:

Lactations:

Unknown if excreted in breast milk 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: