CEPHALEXIN

Indications & Dose:

Susceptible infections due to sensitive Grampositive and Gram-negative bacteria 

• BY MOUTH 

Child 1–11 months: 12.5 mg/kg twice daily, alternatively 125 mg twice daily 

Child 1–4 years: 12.5 mg/kg twice daily, alternatively 125 mg 3 times a day 

Child 5–11 years: 12.5 mg/kg twice daily, alternatively 250 mg 3 times a day

Child 12–17 years: 500 mg 2–3 times a day 

Adult: 250 mg every 6 hours, alternatively 500 mg every 8–12 hours; increased to 1–1.5 g every 6–8 hours, increased dose to be used for severe infections Serious susceptible infections due to sensitive Grampositive and Gram-negative bacteria 

• BY MOUTH

Child 1 month–11 years: 25 mg/kg 2–4 times a day (max. per dose 1 g 4 times a day) 

Child 12–17 years: 1–1.5 g 3–4 times a day Prophylaxis of recurrent urinary-tract infection %

• BY MOUTH

Child: 12.5 mg/kg once daily (max. per dose 125 mg), dose to be taken at night 

Adult: 125 mg once daily, dose to be taken at night

Contraindications:

Infants < 1 mo

 PREGNANCY Not known to be harmful.

 BREAST FEEDING Present in milk in low concentration, but appropriate to use.

RENAL IMPAIRMENT ¶% In adults Max. 3 g daily if eGFR 40–50 mL/ minute/1.73m2. Max. 1.5 g daily if eGFR 10–40 mL/ minute/1.73m2. Max. 750mg daily if eGFR less than 10 mL/minute/1.73m2. % In children Reduce dose in moderate impairment. 

Side Effects:

CNS: Chills, dizziness, fever, headache, paresthesia, weakness

GI: Abdominal pain, anorexia, bleeding; diarrhea, glossitis, increased LFTs, nausea, pseudomembranous colitis, vomiting

GU: Candidiasis, nephrotoxicity, proteinuria, pruritus, vaginitis

HEME: Bone marrow suppression, eosinophilia, hemolytic anemia, lymphocytosis, thrombocytosis

RESP: Dyspnea

SKIN: Dermatitis, rash -urticaria

MISC.: Serum sickness-like syndrome 

Cautions:

Precautions:

Hypersensitivity to penicillins, renal disease 

Interaction:

Drugs

Aminoglycosides: Additive nephrotoxicity Loop diuretics: Increased nephrotoxicity 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: