Ceftazidime

Indications & Dose:

Acute infections due to sensitive Gram-positive and Gramnegative bacteria 

• BY MOUTH

Children (Use paeds suspension) 

Under 2-6 month not recommended 1-12 months, 3.5ml daily, 1-4 year 5ml daily, 5-10 year 10ml daily, over 50kg or over 10 years 1020ml/kg 

Child 6–11 months: 75 mg daily 

Child 1–4 years: 100 mg daily 

Child 5–9 years: 200 mg daily 

Child 10–17 years: 200–400 mg daily, alternatively

100–200 mg twice daily

 Adult: 200–400 mg daily in 1–2 divided doses Uncomplicated gonorrhoea %

• BY MOUTH

Adult: 400 mg for 1 dose

Contraindications:

Infants <6 mo.

 PREGNANCY Not known to be harmful. 

BREAST FEEDING Manufacturer advises avoid unless essential—no information available. 

 RENAL IMPAIRMENT In adults Reduce dose if eGFR less than 20 mL/minute/1.73m2 (max. 200mg once daily).  In children Reduce dose if estimated glomerular filtration rate less than 20 mL/minute/1.73m2.

Side Effects:

Cautions:

Precautions:

Hypersensitivity to penicillins

Interaction:

Drugs

Aminoglycosides: Additive nephrotoxicity

Loop diuretics: Increased nephrotoxicity

Oral anticoagulants: Enhanced hypoprothrombinemia

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Chills, confusion, dizziness, fatigue, fever, headache, lethargy, paresthesia

GI: Anorexia, bleeding; diarrhea, dysgeusia, flatulence, glossitis, heartburn, increased LFTs; nausea, pseudomembranous colitis, vomiting

GU: Candidiasis, nephrotoxicity, proteinuria, pruritus, vaginitis

HEME: Bone marrow suppression eosinophilia, hemolytic anemia, lymphocytosis

RESP: Bronchospasm, dyspnea

SKIN: Exfoliative dermatitis, rash, urticaria

Patient And Carer Advice: