CEFTIZOXIME

Indications & Dose:

Infections of the skin and skin structures, bone and joints, lower respiratory tract, urinary tract; gonorrhea, pelvic inflammatory disease, septicemia, meningitis, intraabdominal infections caused by susceptible organisms 

DOSAGE:

Adults: IM/IV: 1-2 gm every 8-12 hours, up to 2 gm every 4 hours or 4 gm every 8 hours for lifethreatening infection.

Children: > 6 months; 150-200 mg/kg/day divided every 6-8 hours; max 12 gm/day.

Bone Infection: IM/IV:

Adults: 1-2 gm every 8-12 hours. Max: 6 gm/day.

Children: > 6 months: 50 mg/kg every 6-8 hours, not to exceed adult dose.

Meningitis/Speticaemia: IV:

Adults: 3-4 gm every 8 hours.

Children:> 6 months: 50 mg/kg every 6-8 hours, not to exceed adult dose.

ADMINISTRATION: IM: Inject deep IM into large muscle mass.

IV: Inject direct IV over 3-5 minutes. Infuse Intermittent infusion over 30 minutes.

Compatibility: Stable in D51/4NS, DF1/2NS, D5NS, D5W, D10W, LR, NS, sodium bicarbonatee 5%.

Contraindications:

 Infants < 1 mo. 

Side Effects:

Cautions:

Precautions:

Renal impairment. Hypersensitivity to penicillins

Interaction:

Drugs

Aminoglycosides: Additive nephrotoxicity

Loop diuretics: Increased nephrotoxicity

Warnings:

Adverse Effects:

Pain at inj. site, hypersensitivity reactions. GI disturbances, eosinophilia, neutropenia, leucopenia, thrombocytopenia, rise in liver enzymes and blood urea. Positive Coombs test. 

Lactations:

Pregnancy; excreted in human milk in low concentrations 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Dizziness, fever, headache, paresthesia

GI: Abdominal pain, anorexia, bleeding; diarrhea, glossitis, increased LFTs; nausea, psendomembranous colitis, vomiting

GU: Candidiasis, proteinuria, pruritus, vaginitis, nephrotoxcity

HEMS: Bone marrow suppression, eosinophilia, hemolytic anemia

RESP: Dyspnea

SKIN: Dermatitis, rash, urticaria 

Patient And Carer Advice: