AMOXYCILLIN /CLAVULANIC ACID

Indications & Dose:

Infections of the lower respiratory tract, ear, sinuses, skin and soft tissues, urinary tract caused by susceptible organisms

DOSE

Adults Pneumonia and serious infections: 500mg amoxycillin and 125mg calvulanic acid every 8 hours for 7-10 days. Other infections: 250mg of amoxycillin and 125mg of clavulanic acid every 8 hours for 7-10 days.

Children Upto 40kg of body wt.: 6.7mg amoxycillin and 1.7 clavulanic acid per kg body wt. every 8 hour for 7- 10 days. For severe infections: 13.3mg amoxycillin and 3.3 clavulanic acid per kg body wt. for 7-10 days.

Contraindications:

Hypersensitivity to penicillins 

Side Effects:

Cautions:

Precautions:

Hypersensitivity to cephalosporins, renal insufficiency, prolonged or repeated therapy, mononucleosis

Interaction:

Drugs

Atenolol: Reduced serum concentration of atenolol Chloramphenicol: Inhibited antibacterial activity of amoxicillin; administer amoxicillin 3 hours before chloramphenicol

Macrolide antibiotics: Inhibited antibacterial activity of amoxicillin; administer amoxicillin 3 hours before macrolides

Methotrexate: Increased serum methotrexate concentrations

Oral contraceptives: Occasional impairment of oral contraceptive efficacy; consider use of supplementary contraception during cycles in which amoxicillin is used

Tetracyclines: Inhibited antibacterial activity of amoxicillin; administer amoxicillin 3 hours before tetracycline

Warnings:

Adverse Effects:

Lactations:

PREGNANCY AND LACTATION: Excreted into breast milk in low concentrations; no adverse effects have been observed

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Fever, headache

GI: Abdominal pain, black tongue, colitis, diarrhea, (9%) glossitis, increased AST, ALT, nausea, pseudomembranous colitis, vomiting

GU: Moniliasis, vaginitis

HEME: Bone marrow depression, eosinophilia, increased bleeding time

METAB: Alkalosis, hyperkalemia, hypernatremia, hypokalemia

MISC.: Hypersensitivity reactions (rash, urticaria, erythema multiform, exfoliative dermatitis, anaphylaxis) 

Patient And Carer Advice: