CLINDAMYCIN

Indications & Dose:

Infections of the respiratory tract (e.g., empyema, anaerobic pneumonitis, lung abscess), skin and soft tissues, female pelvis and genital tract; septicemia; intra-abdominal infections (e.g., peritonitis, abscess); bone and joint infections; CNS toxoplasmosis in AIDS patients (in combination with pyrimethamine) ; Pneumocystis carinii pneumonia (in combination with primaquine)*; Chlamydia trachomatous infections in women ; acne vulgaris (top formulations); rosacea (top formulations)’; bacterial vaginosis (vag formulation

Contraindications:

Regional enteritis, ulcerative colitis, antibiotic-associated colitis

DOSE

PO

Adult

• 150-450 mg 6 hourly, not to exceed 1.8 g/day.

Children

• Under 1 year, 2.5-5ml ,4-7 every 8 hourly, over 1

year 3-6 mg/kg every 6 hours.

 Inj

Adult

600 mg 2.7 gm by i.m or i.v infusion daily in divided doses

Children

Over 1 month, 15-40 mg/kg in divided doses

COUNCILING: Patient should discontinue immediatly and contact doctor if diarrhoea develops, capsule should swallow with glass of water.

Side Effects:

Cautions:

Precautions:

History of GI disease, liver disease, renal disease, atopic individuals, tartrazine sensitivity (75 and 150 mg caps), elderly, prolonged therapy 

Interaction:

Drugs

Food: Decreased clindamycin concentrations with diet foods containing sodium cyclamate

Kaolin-pectin: Decreased clindamycin concentrations 

Warnings:

Adverse Effects:

Lactations:

Pregnancy ; excreted into breast milk; compatible with breast feeding 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

GI: Abdominal pain, anorexia, diarrhea, increased AST, ALT, bilirubin, alk phosphatase; jaundice, nausea, pseudomembranous colitis, vomiting, weight loss

GU: Urinary frequency, vaginitis, vulvar irritation

HEME: Agranulocytosis, eosinophilia, leukopenia, thrombocytopenia

SKIN: Abscess at inj site, erythema, pain, pruritus, rash, urticaria 

Patient And Carer Advice: