RIFAXIMIN

Indications & Dose:

Travellors Diarrhoea. 

 DOSAGE

Oral: Children >12 years and

 Adults: 

Travelers diarrhea: 200 mg 3 times/day for 3 days 

Contraindications:

Hypersensitivity to rifaximin, other rifamycin antibiotics, or any component of the formulation; diarrhea with fever or blood in the stool.

Pregnancy: pregnancy category C. Due to the limited oral absorption of rifaximin (<0.4%), exposure to the fetus is expected to be extremely low. 

Side Effects:

Cautions:

Precautions:

Interaction:

Warnings:

Efficacy has not been established for the treatment of diarrhea due to pathogens other than E. coli, including C. Jejuni, Shigella and Salmonella. Consider alternative therapy if symptoms persist or worsen after 24-48 hours of treatment. Not for treatment of systemic infections; <1% is absorbed orally. Prolonged use may result in fungal or bacterial superinfection, including C. -associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months postantibiotic treatment. Safety and efficacy have not been established in children <12 years of age. 

Adverse Effects:

Lactations:

 Excretion in breast milk unknown/not recommended 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Incidence of adverse effects reported as 22% occurred more in the placebo group than the rifaximin group except for headache. 2% to 10%: Central nervous system: Headache  placebo 9%)

Increased  Effect/Toxicity There are no known sonificant interactions involving an increase in effect. Decreased Effect

Rifaximin may decrease the levels/effects of; Maravircc Typhoid Vaccine Stability Store at controlled room temperature of 20°C

Dietary Considerations May be taken with or without food.

Administration May be administered with or without food 

Patient And Carer Advice: