TRIMETHOPRIM

Indications & Dose:

To treat UTI caused by Enterobacter species, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, or coagulase-negative staphylococci, including Staphylococcus saprophyticus 

•  BY MOUTH

Adults and children age 12 and over. 300mg once daily

Children age  below 12 . is not applicable

Contraindications:

Hypersensitivity to trimethoprim or its components, megaloblastic anemia from folate deficiency, severe renal impairment (creatinine clearance less than 15 ml/min/ 1.73 m2) 

Side Effects:

Cautions:

Precautions:

Interaction:

DRUGS

bone marrow depressants: Increased risk of leukopenia, thrombocytopenia cyclosporine:

Increased risk of nephrotoxicity dapsone: Increased blood levels and risk of adverse effects (especially methemoglobin-emia) of both drugs folate antagonists: Increased risk of megaloblastic anemia

phenytoin: Decreased phenytoin metabolism, increased risk of phenytoin toxicity

procainamide: Increased blood levels of procainamide and its metabolite, N-acetylprocainamide

rifampin: Increased elimination and decreased effectiveness of trimethoprim

warfarin: Increased anticoagulant activity of warfarin 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Fever, headache

EENT: Glossitis

GI: Abdominal pain, anorexia, diarrhea, elevated liver function test results, epigastric pain, nausea, vomiting

GU: Elevated BUN and serum creatinine levels

HEME: Leukopenia, megaloblastic anemia, methemoglobinemia, neutropenia, thrombocytopenia

SKIN: Exfoliative dermatitis, pruritus, rash

Patient And Carer Advice: