CYCLOSERINE

Indications & Dose:

Pulmonary and extrapulmonary tuberculosis (like all antituberculosis drugs, cycloserine should be administered in conjunction with other eJfective chemotherapy and not as the sole therapeutic agent); acute UTI caused by susceptible strains of gram-positive and gramnegative bacteria, especially Ente robacter spp. and E. coli (when more conventional therapy has failed and when the organism has been demonstrated to be susceptible to the drug)

DOSAGE Adult

PO 250 mg q l2h X 2 wk, then 250 mg q8h X 2 wk, then 250 mg q6h if there are no signs of toxicity; not to exceed I g/day

Child

PO 10-20 mg/kg/day ql2h (max 0.75-1 g); individualize doses 

Contraindications:

Seizure disorders, severe renal disease, alcoholism (chronic), depression, severe anxiety, psychosis 

Side Effects:

CNS: Aggression, anxiety, confusion, depression, drowsiness, headache, lethargy, psychosis, seizures, tremors

CV:. CHF

HEME: Leukocytosis, megaloblastic anemia, vitamin B 12' folic acid deficiency

SKIN: Dermatitis, photosensitivity 

Cautions:

Precautions:

Children, mild renal impairment, anemia 

Interaction:

Drugs

 Isoniazid: Increased risk of CNS toxicity 

Warnings:

Adverse Effects:

Lactations:

Pregnancy category C; excreted into breast milk (72% of serum levels); compatible with breast feeding 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: