ENOXACIN

Indications & Dose:

Uncomplicated urethral or cervical gonorrhea uncomplicated UTI; complicated UTI

DOSE

Adult: Usually 400-800 mg twice daily for 7-14 days.

• Uncomplicated UTl: PO 200 mg q 12h for 3-7 days

• Complicated UTI: PO 400 mg q 12h for 14 days Uncomplicated gonorrhea: PO 4W mg as a single dose

• Renal function impairment (CrCl <30 ml/min/ 1.73 m2): PO after a normal initial dose; use 50% recommended dose q 12h

Children: Not recommended 

Contraindications:

Side Effects:

CNS: Anxiety, depression, dizziness, fatigue, headache, insomnia, seizures, somnolence

EENT: Visual disturbances

GI: Abdominal pain, anorexia, diarrhea, dry mouth; flatulence, heartburn, increased AST, ALT; nausea, pseudomembranous colitis, vomiting

SKIN: Photosensitivity, pruritus, rash 

Cautions:

Precautions:

Children < 17 yr (potential for arthropathy and osteochondrosis), elderly, renal disease, seizure disorders 

Interaction:

Drugs

Aluminum: Reduced absorption of enoxacin; do not take within 4 hr of dose

Antacids: Reduced absorption of enoxacin; do not take within 4 hr of dose

Antipyrine: Inhibits metabolism of antipyrine; increased plasma antipyrine level

Caffeine: Inhibit metabolism of caffeine; increased plasma caffeine level

Calcium: Reduced absorption of enoxacin; do not take within 4 hr of dose

Cimetidine: Reduced absorption of enoxacin

Diazepam: Inhibits metabolism of diazepam; increased plasma diazepam level

Didanosine: Markedly reduced absorption of enoxacin; take enoxacin 2 hr before didanosirie

Famotidine: Reduced absorption of enoxacin

Fenbufen: Coadministration increases seizure risk

Foscarnet: Coadministration increases seizure risk

Iron: Reduced absorption of enoxacin; do not take within 4 hr of dose

Lansoprazole: Reduced absorption of enoxacin

Magnesium: Reduced absorption of enoxacin; do not take within 4 hr of dose

Metoprolol: Inhibits metabolism of metoprolol; increased plasma metoprolol level

Nizatidine: Reduced absorption of enoxacin

Omeprazole: Reduced absorption of enoxacin

Pentoxifylline: Inhibits metabolism of pentoxifylline; increased plasma pentoxifylline level

Phenytoin: Inhibits metabolism of phenytoin; increased plasma phenytoin level

Propranolol: Inhibits metabolism of propranolol; increased plasma propranolol level

Ranitidine: Reduced absorption of enoxacin

Ropinirole: Inhibits metabolism of ropinirole; increased plasma ropinirole level

Sodium bicarbonate: Reduced absorption of enoxacin; do not take within 4 hr of dose

Sucralfate: Reduced absorption of enoxacin; do not take within 4 hr of dose

Tacrine: Inhibits metabolism of tacrine, increased plasma tacrine level

Theobromine: Inhibits metabolism of theobromine; increased plasma theobromine level

Theophylline: Inhibits metabolism of theophylline; cut maintenance theophylline dose in half during therapy with enoxacin

Warfarin: Inhibits metabolism of warfarin; increases hypoprothrombinemic response to warfarin

Zinc: Reduced absorption of enoxacin; do not take within 4 hr of dose 

Warnings:

Adverse Effects:

Lactations:

 Excretion into breast milk unknown; due to the potential for arthropathy and osteochondrosis use extreme caution in nursing mothers 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: