NORFLOXACIN

Indications & Dose:

Uro-genital infections, typhoid fever. Acute bacterial gastro-enteritis. Gonorrhoea. Prophylaxis of sepsis in neutropenic patients. Sexually transmitted disease, eye infection.

DOSE

• BY MOUTH

Adult

Complicated uinary tract infctions 400mg twice daily for 7-10 days (for 3 days in uncomplicated lower urinary tract infections).

Cystitis: 400mg daily for 3 days after meal Chronic relapsing urinary tract infections 400 mg twice daily for 12 weeks, may be reduced to 400mg once daily of adquate suppression with in first 4 week.

Typhoid fever 400mg twice daily for 14 days. Gonorrhoea: 800mg as single dose. Acute bacterial gastro enteritis: 400mg 2-3 times daily for 5 days. Prophylaxis of sepsis in neutropenic patients 400mg 2-3 times daily upto 8 weeks.

Dose should take with water atleast 1 hour before or 2 hour after

Children: Not recommended.

Contraindications:

Hypersensitivity. Pregnancy.

Side Effects:

Nausea, epigastric discomfort, abdominal cramps, anorexia, diarrhoea, sleep disturbances, skin rash and irritability.

Cautions:

Precautions:

Renal impairment, patients with history of epilepsy. Hydration, urinary output. Excessive sunlight.

Breast-feeding: Safety not established.

Old age: May be used. 

Interaction:

Drugs

Anti neoplastic drugs: Decrease serum levels of norfloxacin.

Caffeine: Enhanced efficacy of caffeine.

Oral anticoagulants: Enhanced effects of anticoagulants.

Cyclosporine: Nephrotoxicity increased by norfloxacin.

Theophylline: Increased plasma levels of theophylline resulting in toxicity. 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: