ARTEMETHER/LUMEFANTRINE

Indications & Dose:

Treatment of acute uncomplicated falciparum malaria

Treatment of chloroquine-resistant nonfalciparum malaria 

BY MOUTH

Adult (body-weight 35 kg and above): Initially 4 tablets, followed by 4 tablets for 5 doses each given at 8, 24, 36, 48 and 60 hours (total 24 tablets over 60 hours

Contraindications:

Family history of congenital QT interval prolongation . family history of sudden death . history of arrhythmias . history of clinically relevant bradycardia . history of congestive heart failure accompanied by reduced left ventricular ejection fraction

Side Effects:

Common or very common Abdominal pain . anorexia . arthralgia . asthenia . cough . diarrhoea . dizziness . headache . myalgia . nausea . palpitation . paraesthesia . prolonged QT interval . pruritus . rash . sleep disturbances . vomiting Uncommon Ataxia . clonus . hypoaesthesia

PREGNANCY Toxicity in animal studies with artemether. Manufacturer advises use only if potential benefit outweighs risk.

BREAST FEEDING Manufacturer advises avoid breastfeeding for at least 1 week after last dose. Present in milk in animal studies.

HEPATIC IMPAIRMENT Manufacturer advises caution in severe impairment.

RENAL IMPAIRMENT Manufacturer advises caution in severe impairment. In severe renal impairment monitor ECG and plasma potassium concentration.  

Cautions:

Avoid in acute porphyrias p. 930 . electrolyte disturbances

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

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Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: