Clinical Pharmacology Details


DIHYDROARTEMISININ+PIPERAQUIN PHOSPHATE


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Indications & Dose:

Dihydroartemisinin is effective in all forms of malaria, it is specially effective for the treatment of falciparum malaria and cerebral malaria which are chloroquine resistant or piperaquine resistant.



1.6mg/kg/dose ( Rounded up or down to the nearest half tab) given at 0 hour, 8 hours, 24hours. Alternatively the same total dose may be given once daily for three days.


Children 2 mg/kg body weight with the loading dose doubled.

Contraindications:

Hypersensitivity to any component of this drug., History of arrhythemia, of clinical relevant bradycardia, and of conjestive heart failure accompanied by reduced ventricular ejection fraction; family history of sudden death or of congenital QT interval prolongaion

Side Effects:

Abdominal pain, anorexia, diarrhoea, vomiting, nausea, palpitation, prolongation QT interval, CNS Disturbance

Cautions:

Precautions:

Electrolyte disturbance concomitant use with other drugs known to cause QT interval prolongation, monitor patient unable to take food, Dizziness may effect performance

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: