Methylpredenisolone Sodium Succinate

Indications & Dose:

Allergy, Angioneurotic edema, Asthma, Autoimmune disease, Collagen disease, Crohn’s disease, Dermatological diseases, Eczema, Endocrine disorder, GI diseases, Graft rejection, Leukaemia, Lymphoma, Multiple sclerosis, Nephrotic syndrome, Ocular inflammation, Opthalmic disease, Rejection of organ transplants, Renal diseases, Termination of pregnancy of 13-24 weeks gestation, Traumatic injury, Ulcerative colitis.

• BY INJECTION

Adult: By IM or IV or infusion initially 50mg/500mg group rejection up to 1gm daily upto 3 days. 

Contraindications:

conditions like Cerebral oedema, Cushing’s syndrome, Fungal infection, Peptic ulcer, Psychosis, Viral infection, Herpes simplex keratitis, Syphilis, Tuberculosis, Vaccinia, Hypersensitivity, Varicella. 

Side Effects:

Telangiectasia, Insomnia, Fluid retension, CHO intolerance, Peptic ulceration, Growth retardation, Aseptic bone necrosis, Hypercalciuria, Hypokalemic alkalosis, Mood swings, Acute psychosis, Loss of matrix.

Hypotension, Cardiac arrest, Bronchospasm, Anaphylactic reactions, Cardiovascular collapse. which are responsible for the discontinuation of Methylprednisolone therapy.

Hyperglycemia, Hyperuricemia.

Erythema, Itching, Burning, Acneform, Folliculitis, Striae, Hypertrichosis/gingival hypertrophy, Fragility of skin, Menstrual irregularity, Facial erythema, Perioral dermatitis, Allergic skin reactions, Cushing syndrome, Hypopigmentation, Hyperpigmentation, Ecchymoses, Thin skin, Proximal myopathy, Skin atrophy, Vesiculation, Skin Atrophy. 

Cautions:

Precautions:

Do not have a vaccination, other immunization or any skin test while taking methylprednisolone unless doctor specifically recommended. Avoid use this drug during pregnancy or lactation. This can cause growth suppression in infants, so avoid use. It should be used with caution in patients with liver, kidney, intestinal or heart disease, hypothyroidism, high blood pressure, myasthenia gravis, osteoporosis (brittle bones), herpes eye infection or history of tuberculosis (TB), seizures, ulcers or blood clots. It should be used with caution if patient have a history of ulcers or take large doses of aspirin or other arthritis medication or use alcoholic beverages, because it may make stomach and intestines more susceptible to the irritating effects of alcohol, aspirin and certain arthritis medications, increasing risk of ulcers. Consult the doctor about any injuries or signs of infection (fever, sore throat, pain during urination and muscle aches) that occur during treatment and within 12 months after treatment with this drug, the dose may need to be adjusted or may need to start taking the drug again. It should be used with caution in patient with diabetes, because this drug may increase blood sugar level, test urine for sugar (glucose) frequently and contact the doctor if sugar is present, the dose of diabetes medication and diet may need to be changed. 

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