Ketoconazole

Indications & Dose:

Vaginal candidiasis,* advanced prostate cancer (high doses) 

DOSE

Adult

• PO 200 mg qd initially, increase to 400 mg qd for serious infections or if clinical response insufficient; duration 1-2 wk (candidiasis), 6 mo (other indicated systemic mycoses) Cream; for local use only

Child >2 yr

• PO 3 mg/kg/day as a single dose

Contraindications:

Fungal meningitis (poor CSF penetration)

Side Effects:

Cautions:

Precautions:

Renal disease, hepatic disease, achlorhydria (drug induced), children <2 yr, other hepatotoxic agents, sulfite aensitaiy (CRE)

Interaction:

Warnings:

Adverse Effects:

Lactations:

 Has been used, apparently without harm, for the treatment of vaginal candidiasis during pregnancy; not detected in plasma with chronic shampoo use; unknown if cre absorbed; oral ketoconazole probably excreted in breast milk; use in breast feeding not recommended

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: