Glibenclamide

Indications & Dose:

Non insulin dependent diabetes mellitus, NIDDM type-II. BY MOUTH Adults: Initially 5mg daily. (elderly patient 2.5mg) as a single dose at breakfast adjusted according to response, max: 15mg daily. Children: Not recommended. 

Contraindications:

Pregnancy, diabetic coma, diabetic ketoacidosis, renal failure, hypersensi-tivity. 

Side Effects:

Nausea, vomiting, epigastric discomfort, skin rash, urticaria, thrombocytopenia, leucopenia. 

Cautions:

Precautions:

Strenous physical exercise, in underweight and taking irregu-lar meals can lead to hypoglycaemia. Breast-feeding: Discontinue nursing or drug. Old age: Use with caution

Interaction:

Drugs
Hypoglyacemic effect of glibenclamide is enhanced by: Anticoagulants, Androgens, Chloramphenicol, Clofibrate, Fenfluramine, Fluconazole, Gemfibrozil, Histamine H2 antagonists, Magnesium Salts, Methyldopa, MAOIs, Phenylbutazone, Probenecid, Salicylates, Sulfinpyrazone, Sulfonamides, TCAs & Urinary acidifiers. Hypoglycemic effect of glibenclamide inhibited by the following drugs: S-blockers, Cholestyramine, Diazoxide, Hydantoins, Rifampicin, Thiazide diuretics & Urinary alkalisers. Charcoal: Reduces the absorption of glibenclamide thus reducing its efficacy of toxicity. Digitalis glycosides: Co-administration results in increased digitalis serum levels. 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: