Metformin Hcl + Glibenclamide

Indications & Dose:

Initial therapy for managemement of type 2 diabetes melitus (NIDDM).  Second line therapy for mamagement of type 2 diabetes melitus when hyperglycemia can not be managed with a sulphonylurea or metformin; combination therapy with a thiazolidinedione may be required to achieve control.

• BY MOUTH

Adults:

Initial therapy, 250mg/1.25mg once daily.  Patients with tasting glucose >200mg/dL may start with 250mg/1.25mg twice daily.  Dosage may be increaesd in increments of 250mg/1.25mg at intervals of not less than 2 weeks.  Max. Daily dose 200mg/10mg. Previously treated with a sulphonylurea or metformin alone:Initial 500mg/ 2.5mg or 500mg/5mg twice daily, increase in increments no greater than 500mg/5mg; max daily dose 2000mg/20mg. 

Contraindications:

Renal disease or dysfunction, acute and achronic acidosis, congestive heart failure. 

Side Effects:

Cautions:

Precautions:

Withhold therapy in hypoxemia, de-hydration,or sepsis

Interaction:

Applicable as for individual agent. 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: