Nandrolone Decanonate

Indications & Dose:

Osteoporosis in postmenopausal women (but not recommended)

• BY DEEP INTRAMUSCULAR INJECTION

Adult (female): 50 mg every 3 weeks.

Anemia of renal insufficiency

• BY DEEP INTRAMUSCULAR INJECTION

Adult: Usually: Nandrolone decanoate: 25-100mg i.m. every 3 weeks.

Children: 5-15mg every 3 weeks. 

Contraindications:

Male patients with prostate or breast cancer, hypercalcemia in females with breast cancer, nephrosis, nephrotic phase of nephritis, enhancement of physical appearance or athletic performance 

Side Effects:

Cautions:

Precautions:

Elderly, children. cardiac disease or risk factors for atherosclerosis, renal disease, hepatic disease, seizure disorder, migraine headache, diabetes 

Interaction:

Drugs

Antidiabetic agents: Enhanced hypoglycemic effects

Cyclosporine: Increased cyclosporine concentrations, potential for toxicity

HMG-CoA reductuse inhibitors (lovastatin, pravastatin): Myositis risk increased

Oral anticoagulants:Enhanced hypoprothrombinemic response

Tacrolimus: Increased tacrolimus concentrations, potential for toxicity 

Warnings:

Adverse Effects:

Lactations:

Use extreme caution in nursing mothers 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Choreiform movement, depression, excitation, habituation, insomnia

CV: Edema

EENT: Deepening of voice, hoarseness

GI: Cholestatic jaundice, diarrhea, hepatic necrosis, hepatocellular neoplasms, nausea, peliosis hepatis, vomiting

GU: Amenorrhea, clitoral hypertrophy, decreased breast size, decreased libido, testicular atrophy, vaginitis, virilization

METAB: Decreased glucose tolerance, decreased HDL cholesterol, increased LDL cholesterol, increased serum cholesterol, retention of sodium, chloride, water, potassium, phosphates, calcium

MS: Premature closure of epiphyses in children

SKIN: Acne, alopecia, flushing; hirsutism, rash, sweating 

Patient And Carer Advice: