Ibandronic Acid

Indications & Dose:

Reduction of bone damage in bone metastases in breast cancer

• INITIALLY BY MOUTH

Adult: 50 mg daily, alternatively (by intravenous infusion) 6 mg every 3–4 weeks

Hypercalcaemia of malignancy

Treatment of postmenopausal osteoporosis

• INITIALLY BY MOUTH

Adult (female): 150 mg once a month, alternatively

Contraindications:

Side Effects:

Hypocalcaemia, hypophosphataemia, influenza-like symptoms (including fever, chills, and muscle pain), bone pain; oesophageal reactions (see below), diarrhoea, nausea, vomiting, abdominal pain, dyspepsia, pharyngitis; headache, asthenia; rarely anaemia, hypersensitivity reactions (pruritus, bronchospasm and angioedema reported) 

OESOPHAGEAL REACTIONS: 

Severe oesophageal reactions reported with all oral bisphosphonates; patients should be advised to stop tablets and seek medical attention for symptoms of oesophageal irritation such as dysphagia, pain on swallowing, retrosternal pain, or heartburn 

Cautions:

hepatic impairment; renal impairment; monitor renal function and serum calcium, phosphate and magnesium; cardiac disease (avoid fluid overload); breastfeeding 

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: