Pamidronate Disodium

Indications & Dose:

Hypercalcaemia of malignancy

• BY INTRAVENOUS INFUSION

Adult: 15–60 mg, to be given (via cannula in a relatively large vein) as a single infusion or in divided doses over 2–4 days, dose adjusted according to serum calcium concentration; maximum 90 mg per course

Osteolytic lesions and bone pain in bone metastases associated with breast cancer or multiple myeloma

• BY INTRAVENOUS INFUSION

Adult: 90 mg every 4 weeks, to be administered via cannula in a relatively large vein, dose may alternatively be administered every 3 weeks, to coincide with chemotherapy in breast cancer

Paget’s disease of bone

• BY INTRAVENOUS INFUSION

Adult: 30 mg every week for a 6 week course (total dose 180 mg), alternatively initially 30 mg once weekly for 1 week, then increased to 60 mg every 2 weeks (max. per dose 60 mg) for a 6 week course (total dose 210 mg), to be administered via cannula in a relatively large vein, course may be repeated every 6 months; maximum 360 mg per course

• BY ORALLY:

Adults:

Established osteoporosis:

200mg orally daily.

Paget’s bone disease:

300-600mg orally daily.

Metastasis, multiple myeloma:

300-600mg orally daily.

Hypercalcaemia of malignancy:

15-60mg daily. 

Contraindications:

Side Effects:

CNS: Headache, sieuzers

CV: Hepertension

ENT: Iritis, uveitis

GI: Abdnimol pian anorexia, constipation, nausea, vomiting

GU: Fluid overload, UTI

HEME: Anemia

METAB: Hyperpyrexia, hypokaiemia;* hypomagnesemia, hypophosphatemia

MS: Bone pain

SKIN: Induration, pain on palpitation at site of catheter insertion, redness, swelling 

Cautions:

Precautions:

Pregnancy and severe renal insufficiency. Possibility  of precipitating convulsions.

Interaction:

Drugs

Infusions of solutions containing calcium, hypocalcaemia therapy other disphosphonates, plicamycin. 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: