Zoledronic Acid

Indications & Dose:

Tumour-induced hypercalcaemia of malignancy. Paget’s diseases of bone . Osteolytic bone metastases. 

• BY IJECTION

Adults:

4 mg reconstituted and diluted for infusion with 50 ml of 0.9% w/v saline or 5% w/v glucose solution, given as a single 15 minute intravenous infusion.

Children: Not recommended.

Adult: 5mg IV infusion over at least 15 minutes once a year. 

Contraindications:

Hypersensitivity to bisphosphonates. Pregnancy, lactation

Side Effects:

CNS; Agitation, anxiety, confusion, arthralgia, insomnia, somnolence
Cv ; Chest pain, edema, hypotension, bradycardia
EENT ; Conjunctivitis
Gi ; Abdominal pain, anorexia, constipation, diarrhea, dysphagia, nausea, vomiting.
GU ; Deterioration in renal function, renal failure, UTI
Heme; Abdominal pain, anorexia, constipation, diarrhea, dysphagia, nausea, vomiting.

Cautions:

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Severe renal or hepatic impairment. Cardiac failure. Monitor serum calcium, phosphate and magnesium levels. Monitor renal function. Interactions: Aminoglycosides. 

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: