Strontium Ranelate

Indications & Dose:

Postmenopausal osteoporosis to reduce the risk of vertebral and hip fractures.
DOSAGE:  BY MOUTH 2 g sachet once daily by oral administration, administered in-between meals, at bedtime, preferably at least two hours after eating in a glass of water.
Use in the elderly: No dosage adjustment is required in relation to age. Use in renal impairment: No dosage adjustment is required in patients with mild-to-moderate renal impairment (30-70 ml/min creatinine clearance). Strontium ranelate is not recommended for patients with severe renal impairment (creatinine clearance below 30 ml/ min). Use in hepatic
impairment: As strontium ranelate is not metabolised, no dosage adjustment is required in patients with hepatic impairment.
Use in children and adolescents: Not recommended for use in children and adolescents.

Contraindications:

Hypersensitivity to the active substance or to any of the excipients. 

Side Effects:

Nervous system disorders Common: headache (3.3% vs, 2.7%) Gastrointestinal disorders Common: nausea (7,1% vs. 4.6%), diarrhoea (7,0% vs, 5.0%), loose stools (1,0% vs. 0.2%) Skin and subcutaneous tissue disorders Common: dermatitis (2.3% vs, 2,0%), eczema (1.8% vs. 1.4%) Gastrointestinal disorders Frequency unknown: vomiting, abdominal pain, oral mucosal irritation including stomatitis and/or mouth ulceration Skin and subcutaneous tissue disorders Frequency unknown: hypersensitivity skin reactions including rash, pruritus, urticaria, angioedema, Stevens-Johnson syndrome. Cases of severe hypersensitivity syndromes including drug rash with eosinophilia and systemic symptoms (DRESS). Musculoskeletal and connective tissue disorders
Frequency unknown: musculoskeletal pain including muscle spasm, myalgia, bone pain, arthralgia and pain in extremity. 

Cautions:

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Pregnancy risk factor B, not used in breast feeding woman

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: