Leuprorelin Acetate

Indications & Dose:

Advance prostate cancer  

• BY INJECTION

Adult: Inj 3.75mg as a single dose s.c, i.m, in every month,

Endometriosis;

• BY INJECTION

3.75mg as a single s.c,or i.m inj every month for max; 6 months. Start  during 1st 5 days of cycle . Co- administration HRT to reduce bone loss and vasomotor symptoms.

Uterine fibroid

3.75 mg as s.c or i.m injection every month for 3-4 month, max; 6 months

Children: Not recommended 

Contraindications:

Undiagnosed vaginal bleeding

Side Effects:

CNS: Dizziness, headache, insomnia, pain, hot flashes (50%-80%)
CV: Cardiac murmurs, CHF, ECG changes, edema, hypertension, ischemia thrombosis
Gl: Anorexia, constipation, nausea, vomiting
GU: Amenorrhea, anovulation, urinary frequency, vaginal bleeding, vaginal discharge, vaginitis; gynecomastia/breast tenderness
METAB: Androgen-like effects, decreased libido, decreased testicular size, impotence
MS: Bone pain (with initiation in prostate cancer), myalgia
RESP: Dyspnea, sinuscongestion 

Cautions:

Precautions:

 Edema, hepatic disease. CVA, Ml, seizures, hypetension, diabetes mellitus, thromboembolic disease 

Interaction:

Warnings:

Adverse Effects:

Lactations:

Pregnancy category X; spontaneous abortions or intrauterine growth retardation are possible; not recommended during lactation 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: