Octreotide Acetate

Indications & Dose:

GEP

•  BY INJECTION

Tumours, initially 0.05 mg once or twice daily by s.c inj. increasing to 0.2 mg three times daily if necessary.

Carcinoid crises,

•  BY INJECTION

0.05 mg by i.v. inj. diluted with saline and given as a bolus

Pancreatic surgery;

•  BY INJECTION

0.1 mg by s.c. inj three times daily for 7 days, starting 1 hour before laporatomy.

Acromegaly; 

•  BY INJECTION

when controlled, established, initially 20 mg by intraglutal inj every 4 weeks for 3 months. Adjust subsequent doses according to levels of GH or IGFI and clinical response.

Contraindications:

Side Effects:

Cautions:

Precautions:

Gallbladder disease (stones or sludge in 48% of patients treated for 12 mo; in 2% of patients treated for 1 mo); may affect glycemic control in diabetics 

Interaction:

Warnings:

Adverse Effects:

Lactations:

Pregnancy category B; breast milk excretion unknown 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Dizziness, fatigue, headache, weakness 
CV: Bradycardia (21% in acromegalies), conduction abnormalities, dysrhythmias 
GI: Abdominal discomfort, constipation, diarrhea, distension, flatulence, nausea, pancreatitis, vomiting 
HEME: Vitamin B12 deficiency 
METAB: Goiter, hyperglycemia, hypoglycemia, hypothyroidism 
MS: Bellspalsy leg cramps 
SKIN: Alopecia 
MISC: Local pain on inj

Patient And Carer Advice: