Clinical Pharmacology Details


Somatropin


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Indications & Dose:

Children:


Growth hormone deficiency


•  BY INJECTION


0.025-0.035 mg/kg body weight daily by SC or IM inj.


Turner syndrome


•  BY INJECTION


0.045-0.50 mg/kg body weight daily by SC Injection in evening.


Renal insufficiency


•  BY INJECTION


0.045-0.050 mg/kg body weight daily by SC Inj.


Prader-Willi syndrome


•  BY INJECTION


0.035 mg/kg daily or 1 mg/square meter daily by SC Injection, maximum 2.7 mg daily.


Adults: Initially 0.15-0.3 mg daily by SC Inj. Increase gradually according to individual requirements; maximum 1 mg daily.

Contraindications:

Pregnancy, lactation.


Hypersensitivity to benzyl alcohol, closed epiphyses, evidence of tumor activity and/or active neoplasia; sensitivity to m-cresol or glycerin (Humatrope)

Side Effects:

CNS: Headache, intracranial hypertension
HEME: Leukemia (uncertain relationship)
METAB: Glycosuria, hypercalciuria, hypothyroidism. ketosis, mild hyperglycemia
SKIN: Inflammation at inj site. pain, rash, urticaria
MISC: Antibodies to growth hormone 

Cautions:

Precautions:

Diabetes mellitus, hypothyroidism 

Interaction:

Drugs
No significant

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: