Dapagliflozin

Indications & Dose:

Type 2 diabetes mellitus as monotherapy (if metformin inappropriate) | Type 2 diabetes mellitus in combination with insulin or other antidiabetic drugs (if existing treatment fails to achieve adequate glycaemic control) 

• BY MOUTH

Adult 18–74 years: 10 mg once daily

Adult 75 years and over: Initiation not recommended

DOSE ADJUSTMENTS DUE TO INTERACTIONS

Dose of concomitant insulin or drugs that stimulate insulin secretion may need to be reduced.

Contraindications:

Ketoacidosis

Side Effects:

Common or very common Back pain . constipation .dyslipidaemia . dysuria . genital infection . hypoglycaemia(in combination with insulin or sulphonylurea) . polyuria . sweating . thirst . urinarytract infection

Uncommon Dehydration . dizziness . hypotension .hypovolaemia . nausea . nocturia . raised serum creatinine .raised serum urea . rash

PREGNANCY Avoid—toxicity in animal studies.

BREAST FEEDING Avoid—present in milk in animal studies.

HEPATIC IMPAIRMENT Initial dose 5 mg daily in severe impairment, increased according to response.

RENAL IMPAIRMENT Avoid if eGFR less than 60 mL/minute/1.73m2 (ineffective).

Cautions:

Cardiovascular disease (risk of hypotension) . elderly (risk of hypotension) . electrolyte disturbances . hypotension . raised haematocrit

CAUTIONS, FURTHER INFORMATION

Volume depletion Correct hypovolaemia before starting treatment.

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: